{"id":160,"date":"2018-03-09T17:48:22","date_gmt":"2018-03-09T17:48:22","guid":{"rendered":"http:\/\/antibiotika.kisoc.de\/?page_id=160"},"modified":"2019-11-05T20:57:48","modified_gmt":"2019-11-05T20:57:48","slug":"modul-lilly-tag5-gentamicin","status":"publish","type":"page","link":"http:\/\/antibiotika.kisoc.de\/en\/modul-lilly-tag5-gentamicin","title":{"rendered":"Lilly Benthaus Day 5 Gentamicin"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_tta_tabs active_section=&#8221;1&#8243; pagination_style=&#8221;flat-round&#8221;][vc_tta_section title=&#8221;Microbiological results&#8221; tab_id=&#8221;MirkobiologischerBefund-L-5G-EN&#8221;][vc_row_inner][vc_column_inner width=&#8221;2\/3&#8243;][vc_column_text]<\/p>\n<h1><span> Microbiological results<\/span><strong><\/strong><\/h1>\n<p>[\/vc_column_text][vc_column_text]<\/p>\n<div class=\"wpb_text_column wpb_content_element \">\n<div class=\"wpb_wrapper\">\n<h3>Concentration on agar &#038; Microbial load<\/h3>\n<p>Next we will consider three parameters:<\/p>\n<\/div>\n<\/div>\n<p><strong><\/strong><span><\/span><strong><\/strong>[\/vc_column_text][\/vc_column_inner][vc_column_inner width=&#8221;1\/3&#8243;][vc_single_image image=&#8221;480&#8243; img_size=&#8221;medium&#8221;][\/vc_column_inner][\/vc_row_inner][vc_column_text]\t\t\t\t\t\t<style>\r\n\t\t\t\t<style>\r\n#wpsm_accordion_850 .wpsm_panel-heading{\r\n\tpadding:0px !important;\r\n}\r\n#wpsm_accordion_850 .wpsm_panel-title {\r\n\tmargin:0px !important; \r\n\ttext-transform:none !important;\r\n\tline-height: 1 !important;\r\n}\r\n#wpsm_accordion_850 .wpsm_panel-title a{\r\n\ttext-decoration:none;\r\n\toverflow:hidden;\r\n\tdisplay:block;\r\n\tpadding:0px;\r\n\tfont-size: 18px !important;\r\n\tfont-family: Open Sans !important;\r\n\tcolor:#000000 !important;\r\n\tborder-bottom:0px !important;\r\n}\r\n\r\n#wpsm_accordion_850 .wpsm_panel-title a:focus {\r\noutline: 0px !important;\r\n}\r\n\r\n#wpsm_accordion_850 .wpsm_panel-title a:hover, #wpsm_accordion_850 .wpsm_panel-title a:focus {\r\n\tcolor:#000000 !important;\r\n}\r\n#wpsm_accordion_850 .acc-a{\r\n\tcolor: #000000 !important;\r\n\tbackground-color:#e8e8e8 !important;\r\n\tborder-color: #ddd;\r\n}\r\n#wpsm_accordion_850 .wpsm_panel-default > .wpsm_panel-heading{\r\n\tcolor: #000000 !important;\r\n\tbackground-color: #e8e8e8 !important;\r\n\tborder-color: #e8e8e8 !important;\r\n\tborder-top-left-radius: 0px;\r\n\tborder-top-right-radius: 0px;\r\n}\r\n#wpsm_accordion_850 .wpsm_panel-default {\r\n\t\tborder:1px solid transparent !important;\r\n\t}\r\n#wpsm_accordion_850 {\r\n\tmargin-bottom: 20px;\r\n\toverflow: hidden;\r\n\tfloat: none;\r\n\twidth: 100%;\r\n\tdisplay: block;\r\n}\r\n#wpsm_accordion_850 .ac_title_class{\r\n\tdisplay: block;\r\n\tpadding-top: 12px;\r\n\tpadding-bottom: 12px;\r\n\tpadding-left: 15px;\r\n\tpadding-right: 15px;\r\n}\r\n#wpsm_accordion_850  .wpsm_panel {\r\n\toverflow:hidden;\r\n\t-webkit-box-shadow: 0 0px 0px rgba(0, 0, 0, .05);\r\n\tbox-shadow: 0 0px 0px rgba(0, 0, 0, .05);\r\n\t\tborder-radius: 4px;\r\n\t}\r\n#wpsm_accordion_850  .wpsm_panel + .wpsm_panel {\r\n\t\tmargin-top: 5px;\r\n\t}\r\n#wpsm_accordion_850  .wpsm_panel-body{\r\n\tbackground-color:#ffffff !important;\r\n\tcolor:#000000 !important;\r\n\tborder-top-color: #e8e8e8 !important;\r\n\tfont-size:16px !important;\r\n\tfont-family: Open Sans !important;\r\n\toverflow: hidden;\r\n\t\tborder: 2px solid #e8e8e8 !important;\r\n\t}\r\n\r\n#wpsm_accordion_850 .ac_open_cl_icon{\r\n\tbackground-color:#e8e8e8 !important;\r\n\tcolor: #000000 !important;\r\n\tfloat:right !important;\r\n\tpadding-top: 12px !important;\r\n\tpadding-bottom: 12px !important;\r\n\tline-height: 1.0 !important;\r\n\tpadding-left: 15px !important;\r\n\tpadding-right: 15px !important;\r\n\tdisplay: inline-block !important;\r\n}\r\n\r\n\t\t\t\r\n\t\t\t<\/style>\t\r\n\t\t\t<\/style>\r\n\t\t\t<div class=\"wpsm_panel-group\" id=\"wpsm_accordion_850\" >\r\n\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t<!-- Inner panel Start -->\r\n\t\t\t\t\t<div class=\"wpsm_panel wpsm_panel-default\">\r\n\t\t\t\t\t\t<div class=\"wpsm_panel-heading\" role=\"tab\" >\r\n\t\t\t\t\t\t  <h4 class=\"wpsm_panel-title\">\r\n\t\t\t\t\t\t\t<a  class=\"\"  data-toggle=\"collapse\" data-parent=\"#wpsm_accordion_850 \" href=\"javascript:void(0)\" data-target=\"#ac_850_collapse1\" onclick=\"do_resize()\">\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"ac_open_cl_icon fa fa-minus\"><\/span>\r\n\t\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t\t \r\n\t\t\t\t\t\t\t\t<span class=\"ac_title_class\">\r\n\t\t\t\t\t\t\t\t\tPathogens\t\t\t\t\t\t\t\t<\/span>\r\n\t\t\t\t\t\t\t<\/a>\r\n\t\t\t\t\t\t  <\/h4>\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t<div id=\"ac_850_collapse1\" class=\"wpsm_panel-collapse collapse in\"  >\r\n\t\t\t\t\t\t  <div class=\"wpsm_panel-body\">\r\n\t\t\t\t\t\t\t<p class=\"acc-font\">Today, precise identification of bacterial species is performed using complicated but very quick methods of mass spectrometry. Identification is important as it is used in making a preliminary selection of antibiotics, since not all antibiotics work against all bacteria. The final selection of a medication is based on measured resistances and on patient information (e.g. allergies).<\/p>\t\t\t\t\t\t  <\/div>\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t<!-- Inner panel End -->\r\n\t\t\t\t\t\r\n\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t<!-- Inner panel Start -->\r\n\t\t\t\t\t<div class=\"wpsm_panel wpsm_panel-default\">\r\n\t\t\t\t\t\t<div class=\"wpsm_panel-heading\" role=\"tab\" >\r\n\t\t\t\t\t\t  <h4 class=\"wpsm_panel-title\">\r\n\t\t\t\t\t\t\t<a  class=\"collapsed\"  data-toggle=\"collapse\" data-parent=\"#wpsm_accordion_850 \" href=\"javascript:void(0)\" data-target=\"#ac_850_collapse2\" onclick=\"do_resize()\">\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"ac_open_cl_icon fa fa-plus\"><\/span>\r\n\t\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t\t \r\n\t\t\t\t\t\t\t\t<span class=\"ac_title_class\">\r\n\t\t\t\t\t\t\t\t\tConcentration on agar\t\t\t\t\t\t\t\t<\/span>\r\n\t\t\t\t\t\t\t<\/a>\r\n\t\t\t\t\t\t  <\/h4>\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t<div id=\"ac_850_collapse2\" class=\"wpsm_panel-collapse collapse \"  >\r\n\t\t\t\t\t\t  <div class=\"wpsm_panel-body\">\r\n\t\t\t\t\t\t\t<p class=\"acc-font\">This provides a rough indication of the number of bacterial cells on the agar plate using categories such as \u2018dense\u2019, \u2018substantial\u2019, \u2018thin\u2019 and \u2018isolated\u2019.<\/p>\t\t\t\t\t\t  <\/div>\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t<!-- Inner panel End -->\r\n\t\t\t\t\t\r\n\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t<!-- Inner panel Start -->\r\n\t\t\t\t\t<div class=\"wpsm_panel wpsm_panel-default\">\r\n\t\t\t\t\t\t<div class=\"wpsm_panel-heading\" role=\"tab\" >\r\n\t\t\t\t\t\t  <h4 class=\"wpsm_panel-title\">\r\n\t\t\t\t\t\t\t<a  class=\"collapsed\"  data-toggle=\"collapse\" data-parent=\"#wpsm_accordion_850 \" href=\"javascript:void(0)\" data-target=\"#ac_850_collapse3\" onclick=\"do_resize()\">\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"ac_open_cl_icon fa fa-plus\"><\/span>\r\n\t\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t\t \r\n\t\t\t\t\t\t\t\t<span class=\"ac_title_class\">\r\n\t\t\t\t\t\t\t\t\tMicrobial load\t\t\t\t\t\t\t\t<\/span>\r\n\t\t\t\t\t\t\t<\/a>\r\n\t\t\t\t\t\t  <\/h4>\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t<div id=\"ac_850_collapse3\" class=\"wpsm_panel-collapse collapse \"  >\r\n\t\t\t\t\t\t  <div class=\"wpsm_panel-body\">\r\n\t\t\t\t\t\t\t<p class=\"acc-font\">The microbial load is a more precise indication of the number of bacterial cells per milliliter of material. It can be determined by counting the colonies or by means of quantitative molecular biology methods.<\/p>\t\t\t\t\t\t  <\/div>\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t<!-- Inner panel End -->\r\n\t\t\t\t\t\r\n\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\r\n<script type=\"text\/javascript\">\r\n\t\r\n\t\tfunction do_resize(){\r\n\r\n\t\t\tvar width=jQuery( '.wpsm_panel .wpsm_panel-body iframe' ).width();\r\n\t\t\tvar height=jQuery( '.wpsm_panel .wpsm_panel-body iframe' ).height();\r\n\r\n\t\t\tvar toggleSize = true;\r\n\t\t\tjQuery('iframe').animate({\r\n\t\t\t    width: toggleSize ? width : 640,\r\n\t\t\t    height: toggleSize ? height : 360\r\n\t\t\t  }, 250);\r\n\r\n\t\t\t  toggleSize = !toggleSize;\r\n\t\t}\r\n\t\t\r\n<\/script>\t[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1551730674304{border-top-width: 5px !important;border-right-width: 5px !important;border-bottom-width: 5px !important;border-left-width: 5px !important;padding-top: 15px !important;padding-right: 5px !important;padding-bottom: 5px !important;padding-left: 15px !important;border-left-color: #e0e0e0 !important;border-left-style: dashed !important;border-right-color: #e0e0e0 !important;border-right-style: dashed !important;border-top-color: #e0e0e0 !important;border-top-style: dashed !important;border-bottom-color: #e0e0e0 !important;border-bottom-style: dashed !important;border-radius: 5px !important;}&#8221;]<strong>Material:<\/strong> sputum<\/p>\n<p><strong>Query:<\/strong> pathogen identification<\/p>\n<p><strong>Results of culture:<\/strong><\/p>\n<table width=\"605\">\n<tbody>\n<tr>\n<td width=\"96\"><em>Day<\/em><\/td>\n<td width=\"217\"><em>Pathogens<\/em><\/td>\n<td width=\"141\"><em>Concentration on agar<\/em><\/td>\n<td width=\"151\"><em>Microbial load (cells\/ml)<\/em><\/td>\n<\/tr>\n<tr>\n<td width=\"96\">5<\/td>\n<td width=\"217\"><em>Pseudomonas aeruginosa<\/em><\/td>\n<td width=\"141\">isolated<\/td>\n<td width=\"151\">3,5 x 10^2<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>[\/vc_column_text][vc_btn title=&#8221;Kirby-Bauer test&#8221; style=&#8221;3d&#8221; color=&#8221;peacoc&#8221; align=&#8221;right&#8221; link=&#8221;url:%23KirbyBauer-L-5G-EN|||&#8221;][\/vc_tta_section][vc_tta_section title=&#8221;Kirby-Bauer test&#8221; tab_id=&#8221;KirbyBauer-L-5G-EN&#8221;][vc_row_inner][vc_column_inner width=&#8221;2\/3&#8243;][vc_column_text]<\/p>\n<h1>Determining resistance with the Kirby-Bauer test<\/h1>\n<p>[\/vc_column_text][vc_column_text]<strong>Enter the measured values and mark to indicate which antibiotics Lilly Benthaus\u2019 pathogens are sensitive\/resistant to.<\/strong><\/p>\n<p><strong>\u00a0<\/strong>[\/vc_column_text][\/vc_column_inner][vc_column_inner width=&#8221;1\/3&#8243;][vc_single_image image=&#8221;468&#8243; img_size=&#8221;medium&#8221;][\/vc_column_inner][\/vc_row_inner][vc_raw_html]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[\/vc_raw_html][vc_message]<strong>Tip:<\/strong> If the diameter of the zone of inhibition is below the breakpoint limit, the patient\u2019s pathogens should be considered resistant to the antibiotic in question. If the diameter of the zone of inhibition is above the limit, the patient\u2019s pathogens should be considered sensitive to the antibiotic in question.[\/vc_message][vc_column_text]<strong>Resistances:<\/strong><\/p>\n<table width=\"100%\">\n<tbody>\n<tr>\n<td width=\"25%\"><em>Antibiotic <\/em><\/td>\n<td width=\"25%\"><em>Resistance threshold<\/em><\/p>\n<p><em> (mm)<\/em><\/td>\n<td width=\"25%\"><em>Zone of inhibition <\/em><\/p>\n<p><em>(mm)<\/em><\/td>\n<td width=\"25%\"><em>Day 5<\/em><\/p>\n<p><em>\u00a0sensitive\u00a0\u00a0\u00a0\u00a0\u00a0 resistant<\/em><\/td>\n<\/tr>\n<tr>\n<td width=\"25%\"><em>Ciprofloxacin<\/em><\/td>\n<td width=\"25%\">26<\/td>\n<td width=\"25%\"><input name=\"lilly-tag5-hemmhof-ciprofloxacin\" form=\"form-lilly-day5\" type=\"number\" \/><\/td>\n<td width=\"25%\">\n<fieldset form=\"form-lilly-day5\"><input name=\"lilly-tag5-sensibel-resistent-ciprofloxacin\" value=\"sensibel\" checked=\"checked\" form=\"form-lilly-day5\" type=\"radio\" \/> <input name=\"lilly-tag5-sensibel-resistent-ciprofloxacin\" value=\"resistent\" style=\"margin-left: 50px;\" form=\"form-lilly-day5\" type=\"radio\" \/><\/fieldset>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"25%\"><em>Gentamicin<\/em><\/td>\n<td width=\"25%\">15<\/td>\n<td width=\"25%\"><input name=\"lilly-tag5-hemmhof-gentamicin\" form=\"form-lilly-day5\" type=\"number\" \/><\/td>\n<td width=\"25%\">\n<fieldset form=\"form-lilly-day5\"><input name=\"lilly-tag5-sensibel-resistent-gentamicin\" value=\"sensibel\" checked=\"checked\" form=\"form-lilly-day5\" type=\"radio\" \/> <input name=\"lilly-tag5-sensibel-resistent-gentamicin\" value=\"resistent\" style=\"margin-left: 50px;\" form=\"form-lilly-day5\" type=\"radio\" \/><\/fieldset>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"25%\"><em>Meropenem<\/em><\/td>\n<td width=\"25%\">24<\/td>\n<td width=\"25%\"><input name=\"lilly-tag5-hemmhof-meropenem\" form=\"form-lilly-day5\" type=\"number\" \/><\/td>\n<td width=\"25%\">\n<fieldset form=\"form-lilly-day5\"><input name=\"lilly-tag5-sensibel-resistent-meropenem\" value=\"sensibel\" checked=\"checked\" form=\"form-lilly-day5\" type=\"radio\" \/> <input name=\"lilly-tag5-sensibel-resistent-meropenem\" value=\"resistent\" style=\"margin-left: 50px;\" form=\"form-lilly-day5\" type=\"radio\" \/><\/fieldset>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>[\/vc_column_text][vc_column_text]<\/p>\n<h3>Information on the antibiotics<\/h3>\n<p>\t\t\t\t\t\t<style>\r\n\t\t\t\t<style>\r\n#wpsm_accordion_852 .wpsm_panel-heading{\r\n\tpadding:0px !important;\r\n}\r\n#wpsm_accordion_852 .wpsm_panel-title {\r\n\tmargin:0px !important; \r\n\ttext-transform:none !important;\r\n\tline-height: 1 !important;\r\n}\r\n#wpsm_accordion_852 .wpsm_panel-title a{\r\n\ttext-decoration:none;\r\n\toverflow:hidden;\r\n\tdisplay:block;\r\n\tpadding:0px;\r\n\tfont-size: 18px !important;\r\n\tfont-family: Open Sans !important;\r\n\tcolor:#000000 !important;\r\n\tborder-bottom:0px !important;\r\n}\r\n\r\n#wpsm_accordion_852 .wpsm_panel-title a:focus {\r\noutline: 0px !important;\r\n}\r\n\r\n#wpsm_accordion_852 .wpsm_panel-title a:hover, #wpsm_accordion_852 .wpsm_panel-title a:focus {\r\n\tcolor:#000000 !important;\r\n}\r\n#wpsm_accordion_852 .acc-a{\r\n\tcolor: #000000 !important;\r\n\tbackground-color:#e8e8e8 !important;\r\n\tborder-color: #ddd;\r\n}\r\n#wpsm_accordion_852 .wpsm_panel-default > .wpsm_panel-heading{\r\n\tcolor: #000000 !important;\r\n\tbackground-color: #e8e8e8 !important;\r\n\tborder-color: #e8e8e8 !important;\r\n\tborder-top-left-radius: 0px;\r\n\tborder-top-right-radius: 0px;\r\n}\r\n#wpsm_accordion_852 .wpsm_panel-default {\r\n\t\tborder:1px solid transparent !important;\r\n\t}\r\n#wpsm_accordion_852 {\r\n\tmargin-bottom: 20px;\r\n\toverflow: hidden;\r\n\tfloat: none;\r\n\twidth: 100%;\r\n\tdisplay: block;\r\n}\r\n#wpsm_accordion_852 .ac_title_class{\r\n\tdisplay: block;\r\n\tpadding-top: 12px;\r\n\tpadding-bottom: 12px;\r\n\tpadding-left: 15px;\r\n\tpadding-right: 15px;\r\n}\r\n#wpsm_accordion_852  .wpsm_panel {\r\n\toverflow:hidden;\r\n\t-webkit-box-shadow: 0 0px 0px rgba(0, 0, 0, .05);\r\n\tbox-shadow: 0 0px 0px rgba(0, 0, 0, .05);\r\n\t\tborder-radius: 4px;\r\n\t}\r\n#wpsm_accordion_852  .wpsm_panel + .wpsm_panel {\r\n\t\tmargin-top: 5px;\r\n\t}\r\n#wpsm_accordion_852  .wpsm_panel-body{\r\n\tbackground-color:#ffffff !important;\r\n\tcolor:#000000 !important;\r\n\tborder-top-color: #e8e8e8 !important;\r\n\tfont-size:16px !important;\r\n\tfont-family: Open Sans !important;\r\n\toverflow: hidden;\r\n\t\tborder: 2px solid #e8e8e8 !important;\r\n\t}\r\n\r\n#wpsm_accordion_852 .ac_open_cl_icon{\r\n\tbackground-color:#e8e8e8 !important;\r\n\tcolor: #000000 !important;\r\n\tfloat:right !important;\r\n\tpadding-top: 12px !important;\r\n\tpadding-bottom: 12px !important;\r\n\tline-height: 1.0 !important;\r\n\tpadding-left: 15px !important;\r\n\tpadding-right: 15px !important;\r\n\tdisplay: inline-block !important;\r\n}\r\n\r\n\t\t\t\r\n\t\t\t<\/style>\t\r\n\t\t\t<\/style>\r\n\t\t\t<div class=\"wpsm_panel-group\" id=\"wpsm_accordion_852\" >\r\n\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t<!-- Inner panel Start -->\r\n\t\t\t\t\t<div class=\"wpsm_panel wpsm_panel-default\">\r\n\t\t\t\t\t\t<div class=\"wpsm_panel-heading\" role=\"tab\" >\r\n\t\t\t\t\t\t  <h4 class=\"wpsm_panel-title\">\r\n\t\t\t\t\t\t\t<a  class=\"\"  data-toggle=\"collapse\" data-parent=\"#wpsm_accordion_852 \" href=\"javascript:void(0)\" data-target=\"#ac_852_collapse1\" onclick=\"do_resize()\">\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"ac_open_cl_icon fa fa-minus\"><\/span>\r\n\t\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t\t \r\n\t\t\t\t\t\t\t\t<span class=\"ac_title_class\">\r\n\t\t\t\t\t\t\t\t\tCiprofloxacin\t\t\t\t\t\t\t\t<\/span>\r\n\t\t\t\t\t\t\t<\/a>\r\n\t\t\t\t\t\t  <\/h4>\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t<div id=\"ac_852_collapse1\" class=\"wpsm_panel-collapse collapse in\"  >\r\n\t\t\t\t\t\t  <div class=\"wpsm_panel-body\">\r\n\t\t\t\t\t\t\t<p class=\"acc-font\">Bacteria-killing antibiotic from the class of fluoroquinolones. It works by <b>inhibiting a bacterial enzyme which is needed in copying the DNA during cell division<\/b>. It works well against a broad spectrum of bacteria and is often applied in everyday medical practice for non-life-threatening infections. In the meantime, many resistant strains of different pathogens exist worldwide.<\/p>\t\t\t\t\t\t  <\/div>\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t<!-- Inner panel End -->\r\n\t\t\t\t\t\r\n\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t<!-- Inner panel Start -->\r\n\t\t\t\t\t<div class=\"wpsm_panel wpsm_panel-default\">\r\n\t\t\t\t\t\t<div class=\"wpsm_panel-heading\" role=\"tab\" >\r\n\t\t\t\t\t\t  <h4 class=\"wpsm_panel-title\">\r\n\t\t\t\t\t\t\t<a  class=\"collapsed\"  data-toggle=\"collapse\" data-parent=\"#wpsm_accordion_852 \" href=\"javascript:void(0)\" data-target=\"#ac_852_collapse2\" onclick=\"do_resize()\">\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"ac_open_cl_icon fa fa-plus\"><\/span>\r\n\t\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t\t \r\n\t\t\t\t\t\t\t\t<span class=\"ac_title_class\">\r\n\t\t\t\t\t\t\t\t\tGentamicin\t\t\t\t\t\t\t\t<\/span>\r\n\t\t\t\t\t\t\t<\/a>\r\n\t\t\t\t\t\t  <\/h4>\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t<div id=\"ac_852_collapse2\" class=\"wpsm_panel-collapse collapse \"  >\r\n\t\t\t\t\t\t  <div class=\"wpsm_panel-body\">\r\n\t\t\t\t\t\t\t<p class=\"acc-font\">Bacteria-killing antibiotic from the class of aminoglycosides. It works by <b>inhibiting protein synthesis at the bacterial ribosomes<\/b>. Its effective spectrum is not as wide as that of ciprofloxacin, but it works well against Pseudomonas aeruginosa. Resistances exist worldwide in a few percent of bacteria.<\/p>\t\t\t\t\t\t  <\/div>\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t<!-- Inner panel End -->\r\n\t\t\t\t\t\r\n\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t<!-- Inner panel Start -->\r\n\t\t\t\t\t<div class=\"wpsm_panel wpsm_panel-default\">\r\n\t\t\t\t\t\t<div class=\"wpsm_panel-heading\" role=\"tab\" >\r\n\t\t\t\t\t\t  <h4 class=\"wpsm_panel-title\">\r\n\t\t\t\t\t\t\t<a  class=\"collapsed\"  data-toggle=\"collapse\" data-parent=\"#wpsm_accordion_852 \" href=\"javascript:void(0)\" data-target=\"#ac_852_collapse3\" onclick=\"do_resize()\">\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"ac_open_cl_icon fa fa-plus\"><\/span>\r\n\t\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t\t \r\n\t\t\t\t\t\t\t\t<span class=\"ac_title_class\">\r\n\t\t\t\t\t\t\t\t\tMeropenem\t\t\t\t\t\t\t\t<\/span>\r\n\t\t\t\t\t\t\t<\/a>\r\n\t\t\t\t\t\t  <\/h4>\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t<div id=\"ac_852_collapse3\" class=\"wpsm_panel-collapse collapse \"  >\r\n\t\t\t\t\t\t  <div class=\"wpsm_panel-body\">\r\n\t\t\t\t\t\t\t<p class=\"acc-font\">Bacteria-killing antibiotic from the class of \u03b2-lactams and therefore a relative of penicillin. It works by <b>disrupting the building of the bacterial cell wall <\/b>and covers a very wide spectrum of dangerous pathogens. It is often used against Pseudomonas aeruginosa.<\/p>\t\t\t\t\t\t  <\/div>\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t<!-- Inner panel End -->\r\n\t\t\t\t\t\r\n\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\r\n<script type=\"text\/javascript\">\r\n\t\r\n\t\tfunction do_resize(){\r\n\r\n\t\t\tvar width=jQuery( '.wpsm_panel .wpsm_panel-body iframe' ).width();\r\n\t\t\tvar height=jQuery( '.wpsm_panel .wpsm_panel-body iframe' ).height();\r\n\r\n\t\t\tvar toggleSize = true;\r\n\t\t\tjQuery('iframe').animate({\r\n\t\t\t    width: toggleSize ? width : 640,\r\n\t\t\t    height: toggleSize ? height : 360\r\n\t\t\t  }, 250);\r\n\r\n\t\t\t  toggleSize = !toggleSize;\r\n\t\t}\r\n\t\t\r\n<\/script>\t[\/vc_column_text][vc_btn title=&#8221;Patient consultation&#8221; style=&#8221;3d&#8221; color=&#8221;peacoc&#8221; align=&#8221;right&#8221; link=&#8221;url:%23Patientengespraech-L-5G-EN|||&#8221;][\/vc_tta_section][vc_tta_section title=&#8221;Patient consultation&#8221; tab_id=&#8221;Patientengespraech-L-5G-EN&#8221;][vc_column_text]<\/p>\n<h1>Patient consultation<\/h1>\n<p>[\/vc_column_text][vc_row_inner][vc_column_inner width=&#8221;1\/3&#8243;][vc_single_image image=&#8221;230&#8243; img_size=&#8221;medium&#8221;][\/vc_column_inner][vc_column_inner width=&#8221;2\/3&#8243;][vc_column_text]<\/p>\n<h3>Lilly Benthaus<\/h3>\n<blockquote><p>\u201eI think I\u2019m coughing a little less, but otherwise I haven\u2019t noticed much change from the antibiotic yet. But I was actually feeling pretty well beforehand anyway. In any case I haven\u2019t noticed any side effects.\u201c<\/p><\/blockquote>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_column_text]<label> Notes on the patient consultation<\/label><\/p>\n<p><textarea name=\"patientengespraech-lilly-tag5\" form=\"form-lilly-day5\" cols=\"40\" rows=\"10\" class=\"wpcf7-form-control wpcf7-textarea \"><\/textarea>[\/vc_column_text][vc_btn title=&#8221;New scientific findings&#8221; style=&#8221;3d&#8221; color=&#8221;peacoc&#8221; align=&#8221;right&#8221; link=&#8221;url:%23NeueErkenntnisse-L-5G-EN|||&#8221;][\/vc_tta_section][vc_tta_section title=&#8221;New scientific findings&#8221; tab_id=&#8221;NeueErkenntnisse-L-5G-EN&#8221;][vc_row_inner][vc_column_inner width=&#8221;1\/4&#8243;][vc_single_image image=&#8221;386&#8243; img_size=&#8221;medium&#8221;][\/vc_column_inner][vc_column_inner width=&#8221;3\/4&#8243;][vc_column_text]<\/p>\n<h2>New scientific findings<\/h2>\n<p>[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1551706988114{padding-top: 30px !important;}&#8221;]Experiments performed to date regarding the effectiveness of this idea have yielded mixed results. Some point to the positive option of slowing down the evolution of resistances (Abel zur Wiesch, Kouyos, Abel, Viechtbauer and Bonhoeffer, 2014). Most of the experiments were also performed only in the laboratory \u2013 as yet there are no data from animal experiments or clinical studies to confirm the results (Baym, 2016). It is also not certain whether these exceptional antibiotic interactions still occur under different environmental conditions such as an infected human organ or in the case of different genetic makeups (Baym, 2016).[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner][vc_column_inner width=&#8221;1\/2&#8243;][vc_column_text]<\/p>\n<ol>\n<li>At time t<sub>0<\/sub>\u00a0treatment of the illness which is caused by <span><img decoding=\"async\" src=\"\/wp-content\/uploads\/2018\/04\/Schema-Punkt-Schwarz.png\" \/><\/span> <span>begins with antibiotic AB\u00a0 1\u00a0<img decoding=\"async\" src=\"\/wp-content\/uploads\/2018\/04\/Schema-Pfeil-Lila.png\" \/><\/span>.<\/li>\n<li><span>After some time a few cells of the pathogen <img decoding=\"async\" src=\"\/wp-content\/uploads\/2018\/04\/Schema-Punkt-Schwarz.png\" \/>\u00a0<\/span>develop a resistance to AB 1: <span><img decoding=\"async\" src=\"\/wp-content\/uploads\/2018\/04\/Schema-Punkt-Lila.png\" \/> <\/span>(time t<sub>1<\/sub>). At this point AB 1 may even become ineffective.<\/li>\n<li>Then treatment is switched over to AB 2 <span><img decoding=\"async\" src=\"\/wp-content\/uploads\/2018\/04\/Schema-Pfeil-Gruen.png\" \/><\/span>, which works better against the cells which are resistant to AB 1 (<span><img decoding=\"async\" src=\"\/wp-content\/uploads\/2018\/04\/Schema-Punkt-Lila.png\" \/><\/span>) and kills these off. Now <span><img decoding=\"async\" src=\"\/wp-content\/uploads\/2018\/04\/Schema-Punkt-Schwarz.png\" \/> <\/span>once again has an advantage (time t<sub>2<\/sub>) and prevails.<\/li>\n<li>But in this case as well, after some time a resistance can develop in <span><img decoding=\"async\" src=\"\/wp-content\/uploads\/2018\/04\/Schema-Punkt-Schwarz.png\" \/><\/span> against AB 2 <span><img decoding=\"async\" src=\"\/wp-content\/uploads\/2018\/04\/Schema-Punkt-Gruen.png\" \/><\/span> (time t3) and so the antibiotic is switched again and AB 1\u00a0 <span><img decoding=\"async\" src=\"\/wp-content\/uploads\/2018\/04\/Schema-Pfeil-Lila.png\" \/><\/span> is given, thereby killing off\u00a0 <span><img decoding=\"async\" src=\"\/wp-content\/uploads\/2018\/04\/Schema-Punkt-Gruen.png\" \/><\/span>, which has become collaterally sensitive to AB 1.<\/li>\n<\/ol>\n<p>[\/vc_column_text][\/vc_column_inner][vc_column_inner width=&#8221;1\/2&#8243;][vc_single_image image=&#8221;396&#8243; img_size=&#8221;large&#8221;][\/vc_column_inner][\/vc_row_inner][vc_column_text]If a bacterium develops a resistance against an antibiotic, this resistance could also make the bacterium sensitive to another antibiotic (Szybalski and Bryson, 1952). A trade-off of this type is called collateral sensitivity (Szybalski and Bryson, 1952). If this is taken advantage of in the strategic planning of treatments, it could limit the adaptability of the bacteria (Imamovic and Sommer, 2013; Lazar et al., 2014; Oz et al., 2014). This includes ideas such as periodically switching antibiotics (AB) over the course of treatment:[\/vc_column_text][vc_btn title=&#8221;Daily report&#8221; style=&#8221;3d&#8221; color=&#8221;peacoc&#8221; align=&#8221;right&#8221; link=&#8221;url:%23Tagesbericht-L-5G-EN|||&#8221;][\/vc_tta_section][vc_tta_section title=&#8221;Daily report &#8211; Day 5 Lilly Benthaus&#8221; tab_id=&#8221;Tagesbericht-L-5G-EN&#8221;][vc_row_inner][vc_column_inner width=&#8221;2\/3&#8243;][vc_column_text]<\/p>\n<h1>Daily report &#8211; Day 5 Lilly Benthaus<\/h1>\n<p>[\/vc_column_text][vc_column_text]\n<div class=\"wpcf7 no-js\" id=\"wpcf7-f914-o1\" lang=\"de-DE\" dir=\"ltr\" data-wpcf7-id=\"914\">\n<div class=\"screen-reader-response\"><p role=\"status\" aria-live=\"polite\" aria-atomic=\"true\"><\/p> <ul><\/ul><\/div>\n<form action=\"\/en\/wp-json\/wp\/v2\/pages\/160#wpcf7-f914-o1\" method=\"post\" class=\"wpcf7-form init\" id=\"form-lilly-day5\" aria-label=\"Kontaktformular\" novalidate=\"novalidate\" data-status=\"init\">\n<fieldset class=\"hidden-fields-container\"><input type=\"hidden\" name=\"_wpcf7\" value=\"914\" \/><input type=\"hidden\" name=\"_wpcf7_version\" value=\"6.1.5\" \/><input type=\"hidden\" name=\"_wpcf7_locale\" value=\"de_DE\" \/><input type=\"hidden\" name=\"_wpcf7_unit_tag\" value=\"wpcf7-f914-o1\" \/><input type=\"hidden\" name=\"_wpcf7_container_post\" value=\"0\" \/><input type=\"hidden\" name=\"_wpcf7_posted_data_hash\" value=\"\" \/>\n<\/fieldset>\n<p>Please fill out the form on the previous page.\n<\/p><div class=\"wpcf7-response-output\" aria-hidden=\"true\"><\/div>\n<\/form>\n<\/div>\n[\/vc_column_text][\/vc_column_inner][vc_column_inner width=&#8221;1\/3&#8243;][vc_single_image image=&#8221;482&#8243; img_size=&#8221;medium&#8221;][\/vc_column_inner][\/vc_row_inner][\/vc_tta_section][\/vc_tta_tabs][\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space height=&#8221;60px&#8221;][\/vc_column][\/vc_row][vc_row][vc_column][vc_raw_js]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[\/vc_raw_js][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_tta_tabs active_section=&#8221;1&#8243; pagination_style=&#8221;flat-round&#8221;][vc_tta_section title=&#8221;Microbiological results&#8221; tab_id=&#8221;MirkobiologischerBefund-L-5G-EN&#8221;][vc_row_inner][vc_column_inner width=&#8221;2\/3&#8243;][vc_column_text] Microbiological results [\/vc_column_text][vc_column_text] Concentration on agar &#038; Microbial load Next we will consider three parameters: [\/vc_column_text][\/vc_column_inner][vc_column_inner width=&#8221;1\/3&#8243;][vc_single_image image=&#8221;480&#8243; img_size=&#8221;medium&#8221;][\/vc_column_inner][\/vc_row_inner][vc_column_text][\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1551730674304{border-top-width: 5px !important;border-right-width: 5px !important;border-bottom-width: 5px !important;border-left-width: 5px !important;padding-top: 15px !important;padding-right: 5px !important;padding-bottom: 5px !important;padding-left: 15px !important;border-left-color: #e0e0e0 !important;border-left-style: dashed !important;border-right-color: #e0e0e0 !important;border-right-style: dashed [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":410,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-templates\/template-fullwidth.php","meta":{"footnotes":""},"class_list":["post-160","page","type-page","status-publish","has-post-thumbnail","hentry"],"translation":{"provider":"WPGlobus","version":"3.0.2","language":"en","enabled_languages":["de","en"],"languages":{"de":{"title":true,"content":true,"excerpt":false},"en":{"title":true,"content":true,"excerpt":false}}},"_links":{"self":[{"href":"http:\/\/antibiotika.kisoc.de\/en\/wp-json\/wp\/v2\/pages\/160","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/antibiotika.kisoc.de\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/antibiotika.kisoc.de\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/antibiotika.kisoc.de\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/antibiotika.kisoc.de\/en\/wp-json\/wp\/v2\/comments?post=160"}],"version-history":[{"count":63,"href":"http:\/\/antibiotika.kisoc.de\/en\/wp-json\/wp\/v2\/pages\/160\/revisions"}],"predecessor-version":[{"id":1210,"href":"http:\/\/antibiotika.kisoc.de\/en\/wp-json\/wp\/v2\/pages\/160\/revisions\/1210"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/antibiotika.kisoc.de\/en\/wp-json\/wp\/v2\/media\/410"}],"wp:attachment":[{"href":"http:\/\/antibiotika.kisoc.de\/en\/wp-json\/wp\/v2\/media?parent=160"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}